Instability of cerebral blood vessels and nerves can lead to abnormal sensitivity of the tissues in and around the head. MigraMAXX contains three natural remedies for the prevention of these instabilities. Butterbur (Petasites hybridus), standardized for petasins content and processed to remove undesirable pyrrolizidine alkaloids, has emerged as a powerful influence on vascular tone and nerve sensitivity, partly through inhibiting effects on leukotriene synthesis. Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters. Riboflavin may help correct certain mitochondrial dysfunctions related to instability of cerebral vasculature.